Necrostatins

Typtophan-based drugs that have raised the interest of researchers in possible treatment of heart attack patients. The human body's cells die by a process called necroptosis or apoptosis, and in many diseases and injuries this process kicks in. Cell death is part of various schlerosises, nervous system injuries including strokes, and macular degeneration.

Researchers at Harvard have reported necrostatins may be able to stop this process or at least retard it.

Necrostatin-1 mitigates mitochondrial dysfunction post-spinal cord injury

Necrostatin-1 alleviates reperfusion injury following acute myocardial infarction in pigs

Necrostatin-1 Ameliorates Intracerebral Hemorrhage-Induced Brain Injury in Mice Through Inhibiting RIP1/RIP3 Pathway

The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver

Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury

Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. - Study from China's Cancer Institute

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Use in lung cancer - Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

The cardioprotective effect of necrostatin requires the cyclophilin-D component of the mitochondrial permeability transition pore.

Necroptosis as an alternative form of programmed cell death. - Harvard Medical School

Identification of RIP1 kinase as a specific cellular target of necrostatins - PDF at Nature.com

Necrostatin: a potentially novel cardioprotective agent? - University College London

Discrimination between primary necrosis and apoptosis by necrostatin-1 in Annexin V-positive/propidium iodide-negative cells.

Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway.

Stopping Unwanted Cell Death: Implications for Drug Discovery - Tufts University

These scientists tried using necrostatin-1 to preven alcohol damage of the live, but it didn't work - Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury.

These Japanese researches did have some succes in use of necrostatin-1 to protect neursons. - α-Synuclein and Neuronal Cell Death