Research into Statin Drugs
Less than half the cholesterol in the bloodstream comes from diet.
Most is made by the body – in particular by the liver. Statins target
the –HMG-CoA reductase enzyme in the liver cells. They inhibit this
enzyme to prevent cholesterol synthesis.
Dose-related Effect of Statins in Venous Thrombosis Risk Reduction.
Statin Induced Myopathy and Myalgia: Time Trend Analysis and Comparison of Risk Associated with Statin Class from 1991–2006
Cholesterol: Frined Before Foe
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome.
Inflammatory
markers, cholesterol and statins: pathophysiological role and clinical
importance.
Statins in
the Management of Aneurysmal Subarachnoid Hemorrhage: An Overview
of Animal Research, Observational Studies, Randomized Controlled Trials
and Meta-analyses.
Statin
Therapy in Metabolic Syndrome and Hypertension Post-JUPITER: What
is the Value of CRP?
Associations
between statins and COPD: a systematic review
Comparative
neuroprotective profile of statins in quinolinic acid induced neurotoxicity
in rats.
Effect
of Lipid lowering with rosuvastatin on progression of aortic stenosis:
results of the aortic stenosis progression observation: measuring
effects of rosuvastatin (ASTRONOMER) trial.
Statin
prophylaxis and inflammatory mediators following cardiopulmonary bypass:
a systematic review
Cholesterol
treatment with statins: Who is left out and who makes it to goal?
Impact
of prior statin therapy on arrhythmic events in patients with acute
coronary syndromes (from the Global Registry of Acute Coronary Events
[GRACE]).
Improving
the physician-patient cardiovascular risk dialogue to improve statin
adherence
Study
shows statin benefits last a decade
Pharmacoepidemiology
safety study of fibrate and statin concomitant therapy.
Statins
lower the risk for death, heart attacks, and strokes, even for patients
without cardiovascular disease.
Influenza
Morbidity and Mortality in Elderly Patients Receiving Statins: A Cohort
Study
Statin
therapy at carotid angioplasty and stent placement
Atherosclerosis,
degenerative aortic stenosis and statins.
Adding
exercise training to rosuvastatin treatment: influence on serum lipids
and biomarkers of muscle and liver damage.
The impact
of statins on health services utilization and mortality in older adults
discharged from hospital with ischemic heart disease: a cohort study
Reduced risks
of death and congestive heart failure are associated with statin therapy
administered acutely within the first 24 hours of heart attack.
Statins and bone fractures
Patient Compliance with statins
Statin
use and breast cancer
Statins in
dermatology.
Pharmacokinetic
and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme
A (HMG-CoA) reductase inhibitors
Statin science
Statin
Therapy and Risks for Death and Hospitalization in Chronic Heart Failure
Simvastatin
pretreatment reduces the severity of limb ischemia in an experimental
diabetes model
Other methods of
addressing cholesterol problems
The National Health and Nutrition Examination Survey (NHANES) recently
released a study looking at American cardiovascular health trends
from 1999 to 2006. "Control of blood pressure and glucose and
cholesterol levels has improved since 1999 for adults with cardiovascular
disease and diabetes, but racial, ethnic, or socioeconomic differences
have not narrowed significantly"
Statins and alcohol
A University of Pennsylvania study on the possible use of statins
to prevent decline in lung capacity in former smokers concluded
that while there was some favorable correlation, the scientists could
not definitively establish a link and could not recommend statins
for prevention or treatment of chronic obstructive pulmonary disorder.
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