Research into Statin Drugs
Less than half the cholesterol in the bloodstream comes from diet.
Most is made by the body – in particular by the liver. Statins target
the –HMG-CoA reductase enzyme in the liver cells. They inhibit this
enzyme to prevent cholesterol synthesis.
Study
shows statin benefits last a decade
Incidence of statin hepatotoxicity in patients with
hepatitis C.
Cholesterol, C-reactive protein, and cerebrovascular
events following intensive and moderate statin therapy.
Statin therapy at carotid angioplasty and stent
placement
Statin use in heart failure: a cause for concern?
Reduced risks of death and congestive heart failure
are associated with statin therapy administered acutely within the
first 24 hours of heart attack.
Statins and bone fractures
Patient Compliance with statins
Benefit versus Risk in Statin Treatment
Statin use and breast cancer
Statins in the Treatment of Chronic Heart Failure:
A Systematic Review
Pharmacokinetic and pharmacodynamic alterations
of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
Statin science
Statin use and sex-specific stroke outcomes in
patients with vascular disease
ISIS 301012 Significantly Reduces All Atherogenic
Lipids When Dosed as a Single Agent and When Coadministered With Statins
The effect of statin on the aortic gene expression
profiling
From pathophysiology to targeted therapy for atherothrombosis
Statin
Therapy and Risks for Death and Hospitalization in Chronic Heart Failure
Treatment of experimental autoimmune uveoretinitis
with atorvastatin and lovastatin
Simvastatin pretreatment reduces the severity of
limb ischemia in an experimental diabetes model
Statins and alcohol
A University of Pennsylvania study on the possible use of statins
to prevent decline in lung capacity in former smokers concluded
that while there was some favorable correlation, the scientists could
not definitively establish a link and could not recommend statins
for prevention or treatment of chronic obstructive pulmonary disorder. |