Research into Statin Drugs

Less than half the cholesterol in the bloodstream comes from diet. Most is made by the body – in particular by the liver. Statins target the –HMG-CoA reductase enzyme in the liver cells. They inhibit this enzyme to prevent cholesterol synthesis.

Associations between statins and COPD: a systematic review

Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial.

Statin prophylaxis and inflammatory mediators following cardiopulmonary bypass: a systematic review

Cholesterol treatment with statins: Who is left out and who makes it to goal?

Impact of prior statin therapy on arrhythmic events in patients with acute coronary syndromes (from the Global Registry of Acute Coronary Events [GRACE]).

Improving the physician-patient cardiovascular risk dialogue to improve statin adherence

Study shows statin benefits last a decade

Statins lower the risk for death, heart attacks, and strokes, even for patients without cardiovascular disease.

Incidence of statin hepatotoxicity in patients with hepatitis C.

Cholesterol, C-reactive protein, and cerebrovascular events following intensive and moderate statin therapy.

Influenza Morbidity and Mortality in Elderly Patients Receiving Statins: A Cohort Study

Statin therapy at carotid angioplasty and stent placement

Statin use in heart failure: a cause for concern?

Adding exercise training to rosuvastatin treatment: influence on serum lipids and biomarkers of muscle and liver damage.

The impact of statins on health services utilization and mortality in older adults discharged from hospital with ischemic heart disease: a cohort study

Reduced risks of death and congestive heart failure are associated with statin therapy administered acutely within the first 24 hours of heart attack.

Statins and bone fractures

Patient Compliance with statins

Benefit versus Risk in Statin Treatment

Statin use and breast cancer

Statins in the Treatment of Chronic Heart Failure: A Systematic Review

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

Statin science

Statin use and sex-specific stroke outcomes in patients with vascular disease

ISIS 301012 Significantly Reduces All Atherogenic Lipids When Dosed as a Single Agent and When Coadministered With Statins

The effect of statin on the aortic gene expression profiling

From pathophysiology to targeted therapy for atherothrombosis

Statin Therapy and Risks for Death and Hospitalization in Chronic Heart Failure

Treatment of experimental autoimmune uveoretinitis with atorvastatin and lovastatin

Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model

Other methods of addressing cholesterol problems

The National Health and Nutrition Examination Survey (NHANES) recently released a study looking at American cardiovascular health trends from 1999 to 2006. "Control of blood pressure and glucose and cholesterol levels has improved since 1999 for adults with cardiovascular disease and diabetes, but racial, ethnic, or socioeconomic differences have not narrowed significantly"

Statins and alcohol

A University of Pennsylvania study on the possible use of statins to prevent decline in lung capacity in former smokers concluded that while there was some favorable correlation, the scientists could not definitively establish a link and could not recommend statins for prevention or treatment of chronic obstructive pulmonary disorder.