Research into Statin Drugs

Less than half the cholesterol in the bloodstream comes from diet. Most is made by the body – in particular by the liver. Statins target the –HMG-CoA reductase enzyme in the liver cells. They inhibit this enzyme to prevent cholesterol synthesis.

Dose-related Effect of Statins in Venous Thrombosis Risk Reduction.

Statin Induced Myopathy and Myalgia: Time Trend Analysis and Comparison of Risk Associated with Statin Class from 1991–2006

Cholesterol: Frined Before Foe

Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome.

Inflammatory markers, cholesterol and statins: pathophysiological role and clinical importance.

Statins in the Management of Aneurysmal Subarachnoid Hemorrhage: An Overview of Animal Research, Observational Studies, Randomized Controlled Trials and Meta-analyses.

Statin Therapy in Metabolic Syndrome and Hypertension Post-JUPITER: What is the Value of CRP?

Associations between statins and COPD: a systematic review

Comparative neuroprotective profile of statins in quinolinic acid induced neurotoxicity in rats.

Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial.

Statin prophylaxis and inflammatory mediators following cardiopulmonary bypass: a systematic review

Cholesterol treatment with statins: Who is left out and who makes it to goal?

Impact of prior statin therapy on arrhythmic events in patients with acute coronary syndromes (from the Global Registry of Acute Coronary Events [GRACE]).

Improving the physician-patient cardiovascular risk dialogue to improve statin adherence

Study shows statin benefits last a decade

Pharmacoepidemiology safety study of fibrate and statin concomitant therapy.

Statins lower the risk for death, heart attacks, and strokes, even for patients without cardiovascular disease.

Influenza Morbidity and Mortality in Elderly Patients Receiving Statins: A Cohort Study

Statin therapy at carotid angioplasty and stent placement

Atherosclerosis, degenerative aortic stenosis and statins.

Adding exercise training to rosuvastatin treatment: influence on serum lipids and biomarkers of muscle and liver damage.

The impact of statins on health services utilization and mortality in older adults discharged from hospital with ischemic heart disease: a cohort study

Reduced risks of death and congestive heart failure are associated with statin therapy administered acutely within the first 24 hours of heart attack.

Statins and bone fractures

Patient Compliance with statins

Statin use and breast cancer

Statins in dermatology.

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

Statin science

Statin Therapy and Risks for Death and Hospitalization in Chronic Heart Failure

Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model

Other methods of addressing cholesterol problems

The National Health and Nutrition Examination Survey (NHANES) recently released a study looking at American cardiovascular health trends from 1999 to 2006. "Control of blood pressure and glucose and cholesterol levels has improved since 1999 for adults with cardiovascular disease and diabetes, but racial, ethnic, or socioeconomic differences have not narrowed significantly"

Statins and alcohol

A University of Pennsylvania study on the possible use of statins to prevent decline in lung capacity in former smokers concluded that while there was some favorable correlation, the scientists could not definitively establish a link and could not recommend statins for prevention or treatment of chronic obstructive pulmonary disorder.