Research into Statin Drugs

Less than half the cholesterol in the bloodstream comes from diet. Most is made by the body – in particular by the liver. Statins target the –HMG-CoA reductase enzyme in the liver cells. They inhibit this enzyme to prevent cholesterol synthesis.

Study shows statin benefits last a decade

Incidence of statin hepatotoxicity in patients with hepatitis C.

Cholesterol, C-reactive protein, and cerebrovascular events following intensive and moderate statin therapy.

Statin therapy at carotid angioplasty and stent placement

Statin use in heart failure: a cause for concern?

Reduced risks of death and congestive heart failure are associated with statin therapy administered acutely within the first 24 hours of heart attack.

Statins and bone fractures

Patient Compliance with statins

Benefit versus Risk in Statin Treatment

Statin use and breast cancer

Statins in the Treatment of Chronic Heart Failure: A Systematic Review

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

Statin science

Statin use and sex-specific stroke outcomes in patients with vascular disease

ISIS 301012 Significantly Reduces All Atherogenic Lipids When Dosed as a Single Agent and When Coadministered With Statins

The effect of statin on the aortic gene expression profiling

From pathophysiology to targeted therapy for atherothrombosis

Statin Therapy and Risks for Death and Hospitalization in Chronic Heart Failure

Treatment of experimental autoimmune uveoretinitis with atorvastatin and lovastatin

Simvastatin pretreatment reduces the severity of limb ischemia in an experimental diabetes model

Statins and alcohol

A University of Pennsylvania study on the possible use of statins to prevent decline in lung capacity in former smokers concluded that while there was some favorable correlation, the scientists could not definitively establish a link and could not recommend statins for prevention or treatment of chronic obstructive pulmonary disorder.